UNS Conference Portal, 3rd INTERNATIONAL CONFERENCE ON ADVANCED MATERIAL FOR BETTER FUTURE 2018 (3rd ICAMBF 2018)

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Solidification of meloxicam SNEDDS formulation incorporated into soluble and insoluble carrier using freeze drying method
Ilham Kuncahyo, Syaiful Choiri, Achmad Fudholi

Last modified: 2018-10-07

Abstract


Solidification of liquid SNEDDS formulation is required to enhance the feasibility and flexibility for further formulation. In this study purposed to compare the soluble and insoluble carrier namely mannitol and fumed silica, respectively on the nano-emulsion formation and physical properties. The optimized SNEDDS formulation comprising of virgin olive oil, Tween 80, and PEG 400 and meloxicam was embedded into solid carriers e.g. mannitol and aerosol using a freeze-drying method. The physical mixture was carried out to compare aforementioned method. Vibrational spectroscopy, thermal analysis, and morphological characteristic, droplet size and distribution and drug release were performed to characterize the solid SNEDDS. The result showed that crystallization of meloxicam did not observe in the solid SNEDDS formulations which confirmed by vibrational spectroscopy and thermal analysis. Morphological characteristic of solid SNEDDS was similar to the native carriers. Soluble carrier not affected the formation of the nano-emulsion compared to the insoluble carrier. In addition, the solid SNEDDS enhanced the drug release of meloxicam up to 4 folds increment.


Keywords


solid SNEDDS; mannitol; fumed silica; nanoemulsion; meloxicam